Reply.io vs Smartlead pricing and which is better for cold email

Reply.io and Smartlead are compared because both run cold email sequences across many mailboxes, but they are sold to different buyers. Smartlead is a sending engine built for volume and for agencies: unlimited connected mailboxes on every plan, inbox rotation, warm-up, client workspaces and white label, with plans set by how many emails you send and how many contacts you store. Reply.io is a sales engagement platform: email, LinkedIn, calls and SMS in one sequence, a contact database, and an AI SDR plan, priced by active contacts on its email plan and by user on Multichannel.

We read both pricing pages in October 2026. Smartlead lists Base at $39, Pro at $94, Unlimited Smart at $174 and Unlimited Prime at $379 a month, with 17 percent off on annual billing. Base covers 6,000 sends and 2,000 contacts, Pro 90,000 sends and 30,000 contacts, Smart 150,000 sends and 50,000 contacts, and Prime 500,000 sends and 170,000 contacts with three client workspaces. Reply.io lists Email Volume from $59 a month for 1,000 active contacts, Multichannel from $99 per user, Agency from $166 and the AI SDR plan from $500.

Both vendors now sell sending infrastructure inside the app, which is the part most comparisons leave out. Smartlead sells Google and Outlook mailboxes at $4.50 a month each with domains at $13 a year, and pre-warmed mailboxes at $9 a month with domains at $18 a year. Reply.io sells a new domain from $6 a year plus $5 a mailbox a month, or a pre-warmed domain from $25 a year plus $15 a mailbox. For ten mailboxes that is $45 a month on Smartlead against $50 on Reply.io before domains.